Effective power saving method by on-chip traffic compression in noc-based embedded systems

[EN] of components, relying on an efficient on-chip network (network-on-chip; NoC). As the size of the system increases, NoC performance and power consumption become a central issue. In this project, we design compression strategies at the NoC level reducing the number of transmitted flits and consequently the energy consumed. The provided mechanism relies on the abundance of memory data blocks filled with zeros in the analysed applications, thus easily compressible by using a zero-elimination strategy. We provide a hardware implementation for both compression and decompression end points at a generic network interface (NI). The mechanisms have been designed in isolated mode in order to make them modular and easily adapted to any NI protocol. Results show the effectiveness of the compression and decompression mechanisms and the low overhead they introduce. The percentage of traffic reduced by the compression strategy (it is reduced by a factor of 3) justifies the added resources. This work reflects some parts of the main research directions we tackle in the wider PhD framework. In particular, we propose a method for power efficient memory traffic management. The work presented here represents the initial research directions in simulation development, traffic pattern characterization and initial solutions development[ES] Con los avances de la tecnología, los sistemas en chip multiprocesador (MPSoC) aumentan en número de componentes, apoyándose en una red en el chip (NoC) eficiente. Según crece el tamaño de estos sistemas, la eficiencia de la red tanto temporal como energética se convierte en una parte primordial. En este proyecto diseñamos estrategias de compresión a nivel de red (en la NoC) reduciendo el número de flits transmitidos y por tanto la energía consumida. El método propuesto se basa en la abundancia de bloques de memoria con largas cadenas de ceros que se detectaron en las aplicaciones analizadas. Esta abundancia de ceros facilita la compresión mediante estrategias de eliminación de ceros. Ofrecemos una implementación hardware tanto de la parte de compresión como de la de descompresión sobre un interfaz de red (NI) genérico. Los mecanismos propuestos han sido diseñados de forma aislada para hacerlos modulares y fácilmente adaptables a cualquier protocolo de NI. Los resultados muestran la efectividad de los mecanismos de compresión y descompresión y la escasa penalización que introducen. El porcentaje de tráfico reducido mediante la estrategia de compresión (se reduce con un factor de 3) justifica los recursos extra requeridos. Este trabajo refleja parte de la línea de investigación global que se pretende abordar en el marco más amplio de un doctorado. En particular proponemos un método de gestión del tráfico de memoria energéticamente eficiente. El trabajo presentado aquí representa pues una primera aproximación a la investigación realizando un desarrollo parcial del simulador, caracterización de patrones de tráfico y el desarrollo de una solución parcialSoler Heredia, M. (2013). Effective power saving method by on-chip traffic compression in noc-based embedded systems. http://hdl.handle.net/10251/43774Archivo delegad

Voriconazole Use in Children: Therapeutic Drug Monitoring and Control of Inflammation as Key Points for Optimal Treatment

Infeccions fúngiques pediàtriques; Monitorització terapèutica de fàrmacs; VoriconazolInfecciones fúngicas pediátricas; Monitorización terapéutica de fármacos; VoriconazolPaediatric fungal infections; Therapeutic drug monitoring; VoriconazoleVoriconazole plasma concentrations (PC) are highly variable, particularly in children. Dose recommendations in 2–12-year-old patients changed in 2012. Little data on therapeutic drug monitoring (TDM) after these new recommendations are available. We aimed to evaluate voriconazole monitoring in children with invasive fungal infection (IFI) after implementation of new dosages and its relationship with safety and effectiveness. A prospective, observational study, including children aged 2–12 years, was conducted. TDM was performed weekly and doses were changed according to an in-house protocol. Effectiveness, adverse events, and factors influencing PC were analysed. A total of 229 PC from 28 IFI episodes were obtained. New dosing led to a higher rate of adequate PC compared to previous studies; still, 35.8% were outside the therapeutic range. In patients aged < 8 years, doses to achieve therapeutic levels were higher than recommended. Severe hypoalbuminemia and markedly elevated C-reactive protein were related to inadequate PC. Therapeutic PC were associated with drug effectiveness and safety. Higher doses in younger patients and a dose adjustment protocol based on TDM should be considered. Voriconazole PC variability has decreased with current updated recommendations, but it remains high and is influenced by inflammatory status. Additional efforts to control inflammation in children with IFI should be encouraged.This research was funded by an Investigator Sponsored Research Grant from Pfizer (Grant Number WI182544

Voriconazole Use in Children : Therapeutic Drug Monitoring and Control of Inflammation as Key Points for Optimal Treatment

Voriconazole plasma concentrations (PC) are highly variable, particularly in children. Dose recommendations in 2-12-year-old patients changed in 2012. Little data on therapeutic drug monitoring (TDM) after these new recommendations are available. We aimed to evaluate voriconazole monitoring in children with invasive fungal infection (IFI) after implementation of new dosages and its relationship with safety and effectiveness. A prospective, observational study, including children aged 2-12 years, was conducted. TDM was performed weekly and doses were changed according to an in-house protocol. Effectiveness, adverse events, and factors influencing PC were analysed. A total of 229 PC from 28 IFI episodes were obtained. New dosing led to a higher rate of adequate PC compared to previous studies; still, 35.8% were outside the therapeutic range. In patients aged < 8 years, doses to achieve therapeutic levels were higher than recommended. Severe hypoalbuminemia and markedly elevated C-reactive protein were related to inadequate PC. Therapeutic PC were associated with drug effectiveness and safety. Higher doses in younger patients and a dose adjustment protocol based on TDM should be considered. Voriconazole PC variability has decreased with current updated recommendations, but it remains high and is influenced by inflammatory status. Additional efforts to control inflammation in children with IFI should be encouraged

Estrategias docentes para la adaptación de la docencia en Ciencias Jurídicas al entorno on line y semipresencial

The health situation caused by COVID-19 has forced Spanish universities to adopt tools and measures aimed at adapting e-learning education. The teaching of legal subjects was initially at a disadvantage, as it usually made use of traditional methodologies. To solve this problem, a group of lecturers from the UA and the UMH have designed and implemented a series of strategies and methodologies in order to adapt teaching to the virtual environment in a satisfactory manner. The present work gathers and exposes the experiences deployed during the academic year 2020/2021 in certain subjects in the legal field. The analysis of these experiences shows that the current catalogue of technological tools and methodologies makes it possible to achieve the aforementioned objective of adapting to the virtual environment. However, there are a series of factors beyond the control of the teaching staff and which require the commitment of the rest of the members of the university community.La situación sanitaria provocada por la COVID-19 ha forzado a las universidades españolas a adoptar herramientas y medidas orientadas a una adaptación de la enseñanza e-learning. La docencia en materias jurídicas partía de una situación inicial de desventaja al hacer uso habitualmente de metodologías de carácter tradicional. Para solventar este problema, un grupo de profesoras y profesores de la UA y la UMH ha diseñado e implementado una serie de estrategias y metodologías docentes con el fin de adaptar la enseñanza al entorno virtual de manera satisfactoria. El presente trabajo recoge y expone las experiencias docentes desplegadas durante el curso académico 2020/2021 en determinadas asignaturas del ámbito jurídico. Del análisis de estas experiencias se deriva que el catálogo actual de herramientas tecnológicas y metodologías docentes permite alcanzar el citado objetivo de adaptación al entorno virtual. No obstante, existen una serie de factores que escapan al control del profesorado y que requieren el compromiso del resto de miembros de la comunidad universitaria

Guía docente común de las titulaciones de Ingeniero en Electrónica en las universidades andaluzas

El presente documento constituye el resultado del trabajo elaborado de acuerdo con la Convocatoria de Elaboración de Guías Docentes de Titulaciones Andaluzas conforme al Sistema de Créditos Europeos (años 2005/2006) de la Dirección General de Universidades, dependiente de la Secretaría General de Universidades, Investigación y Tecnología de la Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucía

Mountain strongholds for woody angiosperms during the Late Pleistocene in SE Iberia

Mediterranean mountains played an essential role during glacial periods as vegetation refugia. The SE Iberia Late Pleistocene woody angiosperm fossil and floristic evidences are reviewed in the context of phylogeographical studies aiming to identify (i) spatial patterns related to woody angiosperms glacial survival, (ii) structural and functional characteristics of montane refugia, and (iii) gaps in knowledge on the woody angiosperm patterns of survival in Mediterranean mountains. The distribution of palaeobotanical data for SE Iberia refugia has been found to be taphonomically biased due to the scarcity of available and/or studied high-altitude Late Pleistocene sites. However, Siles Lake data together with floristic inference provide evidences for woody angiosperms’ survival in a high-altitude Mediterranean area. The main features boosting survival at montane contexts are physiographic complexity and water availability. Phylogeography studies have mainly been conducted at a continental scale. Although they cohere with palaeobotanical data to a broad scale, a general lack of sampling of SE Iberian range-edge populations, as well as misconceptions about the origin of the populations sampled, impede to infer the proper location of woody angiosperms’ mountain refugia and their importance in the post-glacial European colonisation. We conclude that floristic, geobotanical, palaeobotanical, ethnographical and genetic evidence should be merged to gain a deeper understanding on the role played by Mediterranean mountains as glacial refugia in order to explain the current distribution of many plants and the large biodiversity levels encountered in Mediterranean mountain areas. This is hallmark for effective and efficient conservation and management

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management

Background: Immunodeficiencies (ID), in particular primary immunodeficiencies (PID), are often associated with haematological manifestations, such as peripheral cytopenias or lymphoproliferative syndromes. Early diagnosis and management have significant prognostic implications. Secondary immunodeficiencies (SID) may also be induced by oncohaematological diseases and their treatments. Haematologists and oncologists must therefore be aware of the association between blood disorders and cancer and ID, and be prepared to offer their patients appropriate treatment without delay. Our aim was to define the warning signs of primary and secondary IDs in paediatric and adult patients with oncohaematological manifestations.Methods: A multidisciplinary group of six experts (2 haematologists, 2 immunologists, and 2 paediatricians specializing in ID) conducted a literature review and prepared a document based on agreements reached an in-person meeting. An external group of 44 IDs specialists from all over Spain assessed the document and were consulted regarding their level of agreement.Results: This document identifies the haematological and extra-haematological diseases that should prompt a suspicion of PIDs in adults and children, in both primary care and haematology and oncology departments. Cytopenia and certain lymphoproliferative disorders are key diagnostic pointers. The diagnosis must be based on a detailed clinical history, physical exploration, complete blood count and standard laboratory tests. The immunological and haematological tests included in the diagnostic process will depend on the care level. Patients who are candidates for immunoglobulin replacement therapy must be carefully selected, and treatment should be offered as soon as possible to avoid the development of complications. Finally, this document recommends procedures for monitoring these patients.Conclusions: This document combines scientific evidence with the opinion of a broad panel of experts, and emphasizes the importance of an early diagnosis and treatment to avoid complications. The resulting document is a useful tool for primary care physicians and specialists who see both adult and paediatric patients with oncohaematological diseases

Directional intention identification for walking support using an omni-directional walker

Soler Heredia, M. (2011). Directional intention identification for walking support using an omni-directional walker. http://hdl.handle.net/10251/10218.Archivo delegad

Red 5321. Estrategias para la adaptación de la docencia sobre materias jurídicas al entorno on line

La Red está formada por un grupo de profesores de la Universidad de Alicante y de la Universidad Miguel Hernández de Elche que imparten diversas asignaturas jurídicas en las que ha puesto en práctica distintas estrategias para poder adaptar las clases presenciales a los sistemas de docencia dual y on line, con el fin de identificar ventajas e inconvenientes y presentar propuestas de mejora. El profesorado ha plasmado la información de su experiencia docente en fichas y la opinión del alumnado se ha recabado por medio de encuestas. Las encuestas indican que el alumnado tiene una opinión muy favorable a esta adaptación y gran parte recomendaría las medidas implementadas por los docentes que integran esta Red. No obstante, el profesorado refleja que también hay ciertos aspectos que se deben reforzar, como la fluidez de la comunicación en el aula virtual con los y las estudiantes o la mejora de las infraestructuras y los sistemas informáticos